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The Sound of Evolution
Tolazamide
Mechanism of action:
Tolazamide is a sulfonylurea derivative. Tolazamide binds to and inhibits sulfonylurea receptor 1 on the membrane of pancreatic beta cells. This receptor is the regulatory subunit of the ATP-sensitive potassium channel. When tolazamide inhibits this receptor, potassium efflux decreases, causing membrane depolarization. Depolarization then opens calcium channels, increasing calcium influx and promoting insulin release.
Reference(s):
1. Tal A et al. (1993). Oral hypoglycemic agents in the treatment of type II diabetes. Am Fam Physician.
2. Granberry MC et al. (2005). Cardiovascular risk factors associated with insulin resistance: effects of oral antidiabetic agents. Am J Cardiovasc Drugs.
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