The Sound of Evolution
Tolmetin
Mechanism of action:
Tolmetin is an arylacetic acid derivative. Tolmetin inhibits cyclooxygenase, including both COX-1 and COX-2, blocking the conversion of arachidonic acid into prostaglandins and thromboxanes, thereby reducing inflammatory signaling, pain sensitization, and fever responses.
Reference(s):
1. Burdan F et al. (2004). Gastrointestinal and hepatic toxicity of selective and non-selective cyclooxygenase-2 inhibitors in pregnant and non-pregnant rats. Pharmacol Res.
2. Capasso A et al. (1997). Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. Eur J Pharmacol.
3. Kirkova M et al. (2007). In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs. Auton Autacoid Pharmacol.