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The Sound of Evolution
Tolterodine
Mechanism of action:
Tolterodine is a muscarinic acetylcholine receptor antagonist. Tolterodine competitively antagonizes M3 muscarinic receptors on the bladder detrusor muscle, blocking the binding of acetylcholine released by the parasympathetic nervous system and thereby inhibiting detrusor contraction signaling.
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Schneider T et al. (2004). Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther.
3. McNamara A et al. (2009). Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist. Eur J Pharmacol.
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