The Sound of Evolution
Torsemide
Mechanism of action:
Torsemide is a loop diuretic and a sulfonylurea derivative. In the thick ascending limb of the loop of Henle in the kidney, the Na+/K+/2Cl- cotransporter is responsible for moving these three ions from the tubular lumen into tubular epithelial cells. Torsemide binds to this transporter protein and inhibits the reabsorption of Na+, K+, and Cl-, increasing sodium and water excretion and thereby affecting body fluid volume and blood pressure regulation.
Reference(s):
1. Lopez B et al. (2008). Myocardial fibrosis in chronic kidney disease: potential benefits of torasemide. Kidney Int Suppl.
2. Li XM et al. (2013). Could torasemide be a prophylactic agent of contrast induced acute kidney injury? A review about this field. Eur Rev Med Pharmacol Sci.
3. Buggey J et al. (2015). A reappraisal of loop diuretic choice in heart failure patients. Am Heart J.