The Sound of Evolution
Trandolapril
Mechanism of action:
Trandolapril is an angiotensin-converting enzyme inhibitor. After hepatic hydrolysis in the body, trandolapril is converted into its active form, trandolaprilat, which inhibits the function of angiotensin-converting enzyme. This enzyme normally converts angiotensin I into angiotensin II, which promotes vasoconstriction and raises blood pressure. When trandolaprilat inhibits angiotensin-converting enzyme, angiotensin II levels decrease, leading to reduced vasoconstrictive signaling and a lower hemodynamic burden.
Reference(s):
1. Berl T et al. (2009). Review: renal protection by inhibition of the renin-angiotensin-aldosterone system. J Renin Angiotensin Aldosterone Syst.
2. Conen H et al. (1993). Pharmacologic profile of trandolapril, a new angiotensin-converting enzyme inhibitor. Am Heart J.
3. Diaz A et al. (2008). Update on the use of trandolapril in the management of cardiovascular disorders. Vasc Health Risk Manag.