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The Sound of Evolution
Triamcinolone
Mechanism of action:
Triamcinolone is a synthetic glucocorticoid. As a lipophilic molecule, triamcinolone can freely cross the cell membrane. After binding to the glucocorticoid receptor in the cytoplasm, it forms a ligand-receptor complex that translocates into the nucleus, where it upregulates the expression of anti-inflammatory genes such as annexin A1 and suppresses the expression of pro-inflammatory genes such as IL-1, IL-2, IL-6, and TNF-α.
Reference(s):
1. Florini JR et al. (1961). Metabolic fate of a synthetic corticosteroid (triamcinolone) in the dog. J Biol Chem.
2. Argenti D et al. (1999). A pharmacokinetic study to evaluate the absolute bioavailability of triamcinolone acetonide following inhalation administration. J Clin Pharmacol.
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