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The Sound of Evolution
Trifluoperazine
Mechanism of action:
Trifluoperazine is a phenothiazine derivative. It primarily blocks dopamine D2 receptors, which are Gi/o protein-coupled receptors, in the mesolimbic pathway, thereby reducing the positive symptoms caused by excessive dopaminergic activity.
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Seeman P et al. (2002). Atypical antipsychotics: mechanism of action. Can J Psychiatry.
3. Lahti RA et al. (1993). Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. Eur J Pharmacol.
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