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The Sound of Evolution
Trihexyphenidyl
Mechanism of action:
Trihexyphenidyl is a centrally acting muscarinic acetylcholine receptor antagonist. It inhibits the binding of acetylcholine to M1 muscarinic receptors, thereby reducing cholinergic neurotransmission.
Reference(s):
1. Giachetti A et al. (1986). Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine. Br J Pharmacol.
2. Downs AM et al. (2019). Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia. Neurobiol Dis.
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