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The Sound of Evolution
Trimethoprim
Mechanism of action:
Trimethoprim is an antifolate antibacterial agent and a diaminopyrimidine derivative. It selectively inhibits bacterial dihydrofolate reductase, preventing the conversion of dihydrofolic acid into tetrahydrofolic acid. This leads to reduced synthesis of DNA, RNA, and proteins, preventing normal bacterial proliferation.
Reference(s):
1. Brumfitt W et al. (1993). Reassessment of the rationale for the combinations of sulphonamides with diaminopyrimidines. J Chemother.
2. Brumfitt W et al. (1994). Limitations of and indications for the use of co-trimoxazole. J Chemother.
3. Bean DC et al. (2005). Resistance among Escherichia coli to sulphonamides and other antimicrobials now little used in man. J Antimicrob Chemother.
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