Triptorelin

Triptorelin is a gonadotropin-releasing hormone analog and a synthetic peptide. In the initial phase, continuous stimulation of gonadotropin-releasing hormone receptors in the anterior pituitary by triptorelin causes a temporary rise in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, which in turn briefly increases testosterone in males or estrogen in females. With continued administration, prolonged receptor stimulation leads to desensitization and downregulation of gonadotropin-releasing hormone receptors, causing a marked decline in pituitary LH and FSH secretion. As a result, testosterone in males can be reduced to castration levels, and estrogen in females can be greatly lowered.