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The Sound of Evolution
Tropisetron
Mechanism of action:
Tropisetron is a selective 5-HT3 receptor antagonist. Chemotherapy or radiotherapy stimulates enterochromaffin cells in the gut to release large amounts of serotonin (5-HT). After serotonin activates 5-HT3 receptors on the vagus nerve, vomiting signals are transmitted to the central nervous system. Tropisetron binds to and blocks 5-HT3 receptors, suppressing 5-HT3 receptor-mediated vagal afferent signaling and reducing activation of the vomiting reflex pathway.
Reference(s):
Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
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