The Sound of Evolution
Ulipristal acetate
Mechanism of action:
Ulipristal acetate is a selective progesterone receptor modulator and a synthetic steroid. It acts on the hypothalamic-pituitary-ovarian axis to suppress or delay the luteinizing hormone surge, thereby inhibiting ovulation. Ulipristal acetate also alters the endometrial response to progesterone, resulting in reduced endometrial maturation and decreased suitability for embryo implantation.
Reference(s):
1. Pohl O et al. (2013). Ulipristal acetate - safety and pharmacokinetics following multiple doses of 10-50 mg per day. J Clin Pharm Ther.
2. Melis GB et al. (2012). Pharmacokinetic evaluation of ulipristal acetate for uterine leiomyoma treatment. Expert Opin Drug Metab Toxicol.
3. Gemzell-Danielsson K et al. (2013). Emergency contraception. Gynecol Endocrinol.