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Umeclidinium


Mechanism of action:

Umeclidinium is a bronchodilator with antimuscarinic activity and belongs to the quaternary ammonium compounds. It selectively antagonizes muscarinic acetylcholine receptors on bronchial smooth muscle, especially the M3 receptor, which is a Gq/11 protein-coupled receptor. By blocking the action of acetylcholine, it lowers intracellular calcium concentration and causes bronchial smooth muscle relaxation.

Reference(s):

1. Feldman GJ et al. (2013). The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects. Ther Adv Respir Dis. 


2. Decramer M et al. (2013). Bronchodilation of umeclidinium, a new long-acting muscarinic antagonist, in COPD patients. Respir Physiol Neurobiol.

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