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The Sound of Evolution
Valsartan
Mechanism of action:
Valsartan is an angiotensin II receptor blocker. Under normal conditions, angiotensin II acts through the AT1 receptor to induce contraction of vascular smooth muscle and raise blood pressure. By blocking the AT1 receptor, valsartan causes peripheral vasodilation, lowers systemic vascular resistance, and reduces the pressor signaling mediated by angiotensin II.
Reference(s):
1. Black HR et al. (2009). Valsartan: more than a decade of experience. Drugs.
2. Fogari R et al. (2011). A drug safety evaluation of valsartan. Expert Opin Drug Saf.
3. McInnes GT et al. (1999). Clinical advantage of valsartan. Cardiology.
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