The Sound of Evolution
Venlafaxine
Mechanism of action:
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor. Venlafaxine selectively inhibits the serotonin transporter and norepinephrine transporter on presynaptic neurons, preventing the reuptake of serotonin and norepinephrine from the synaptic cleft and thereby enhancing the actions of both neurotransmitters in the central nervous system.
Reference(s):
1. Ozyalcin SN et al. (2005). The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache.
2. Kennedy SH et al. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments. Can J Psychiatry.
3. Pringsheim T et al. (2012). Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci.