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The Sound of Evolution
Verapamil
Mechanism of action:
Verapamil is a calcium channel blocker and a phenylalkylamine derivative. Verapamil inhibits L-type calcium channels in the myocardium and cardiac conduction system, lowering cytosolic calcium levels, reducing myocardial contractility, suppressing atrioventricular nodal conduction, and decreasing myocardial oxygen demand.
Reference(s):
1. Bellamy WT et al. (1996). P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol.
2. Ahmed JH et al. (1991). The influence of age on the pharmacokinetics of verapamil. Pharmacol Res.
3. Dadashzadeh S et al. (2006). The effect of gender on the pharmacokinetics of verapamil and norverapamil in human. Biopharm Drug Dispos.
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