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The Sound of Evolution
Vidarabine
Mechanism of action:
Vidarabine is a purine nucleoside analog and an adenosine derivative. After entering virus-infected cells, vidarabine is phosphorylated by host cell kinases to vidarabine triphosphate, which competitively inhibits viral DNA polymerase and prevents viral DNA replication. It can also be mistakenly incorporated into viral DNA, resulting in abnormal viral DNA structure.
Reference(s):
1. Suzuki M et al. (2006). Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res.
2. Sagar S et al. (2010). Antiviral lead compounds from marine sponges. Mar Drugs.
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