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The Sound of Evolution
Vigabatrin
Mechanism of action:
Vigabatrin is a GABA (gamma-aminobutyric acid) metabolism inhibitor. Vigabatrin irreversibly inhibits GABA transaminase, preventing the normal metabolic clearance of GABA and increasing GABA concentrations in the brain. This leads to increased activation of GABA_A and GABA_B receptors, neuronal hyperpolarization, and enhanced inhibitory neurotransmission in the central nervous system.
Reference(s):
1. Gram L et al. (1989). Experimental studies of the influence of vigabatrin on the GABA system. Br J Clin Pharmacol.
2. Zwanzger P et al. (2001). Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers. Neuropsychopharmacology.
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