The Sound of Evolution
Vilanterol
Mechanism of action:
Vilanterol is a selective long-acting beta2-adrenergic receptor agonist. Vilanterol binds to beta2-adrenergic receptors on the membrane of bronchial smooth muscle cells and activates adenylyl cyclase, increasing intracellular cAMP levels. This subsequently activates protein kinase A (PKA), lowers cytosolic Ca2+ concentration, and promotes smooth muscle relaxation. The final result is relaxation of bronchial smooth muscle and bronchodilation.
Reference(s):
1. Harrell AW et al. (2013). Metabolism and disposition of vilanterol, a long-acting beta(2)-adrenoceptor agonist for inhalation use in humans. Drug Metab Dispos.
2. Spyratos D et al. (2015). Umeclidinium bromide/vilanterol combination in the treatment of chronic obstructive pulmonary disease: a review. Ther Clin Risk Manag.