The Sound of Evolution
Vilazodone
Mechanism of action:
Vilazodone is a serotonin reuptake inhibitor and partial agonist. Vilazodone inhibits the serotonin transporter in neurons, increasing the concentration of serotonin (5-HT) in the synaptic cleft and enhancing serotonergic activity. In addition, vilazodone acts as a partial agonist at both presynaptic and postsynaptic 5-HT1A receptors. Presynaptically, it can reduce excessive negative feedback inhibition; postsynaptically, it can help reduce anxiety and regulate mood.
Reference(s):
1. Cruz MP et al. (2012). Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T.
2. Chavan BB et al. (2017). Identification and characterization of vilazodone metabolites in rats and microsomes by ultrahigh-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom.
3. Wang SM et al. (2013). A review of current evidence for vilazodone in major depressive disorder. Int J Psychiatry Clin Pract.