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The Sound of Evolution
Viloxazine
Mechanism of action:
Viloxazine is a norepinephrine reuptake inhibitor. Viloxazine inhibits the norepinephrine transporter in neurons, blocking the reuptake of norepinephrine and increasing its concentration in the synaptic cleft, thereby enhancing noradrenergic activity.
Reference(s):
1. Pinder RM et al. (1977). Viloxazine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs.
2. Kergueris MF et al. (1989). Comparative pharmacokinetic study of conventional and sustained-release viloxazine in normal volunteers. Neuropsychobiology.
3. Yu C et al. (2020). Metabolism and in vitro drug-drug interaction assessment of viloxazine. Xenobiotica.
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