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The Sound of Evolution
Vincristine
Mechanism of action:
Vincristine is a vinca alkaloid and a microtubule inhibitor. Vincristine binds specifically to beta-tubulin and prevents the normal polymerization of alpha/beta-tubulin dimers into microtubules. As a result, microtubules cannot form properly, the mitotic spindle also fails to form normally, and the cell becomes arrested in metaphase.
Reference(s):
1. Graf WD et al. (1996). Severe vincristine neuropathy in Charcot-Marie-Tooth disease type 1A. Cancer.
2. Qweider M et al. (2007). Inadvertent intrathecal vincristine administration: a neurosurgical emergency. Case report. J Neurosurg Spine.
3. Johnson IS et al. (1963). The vinca alkaloids: a new class of oncolytic agents. Cancer Res.
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