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The Sound of Evolution
Vinorelbine
Mechanism of action:
Vinorelbine is a vinca alkaloid and a microtubule inhibitor. Vinorelbine binds specifically to beta-tubulin and prevents the normal polymerization of alpha/beta-tubulin dimers into microtubules. As a result, microtubules cannot form properly, the mitotic spindle also fails to form normally, and the cell becomes arrested in metaphase.
Reference(s):
1. Marty M et al. (2001). Oral vinorelbine pharmacokinetics and absolute bioavailability study in patients with solid tumors. Ann Oncol.
2. Piccirillo MC et al. (2010). Vinorelbine for non-small cell lung cancer. Expert Opin Drug Saf.
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