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The Sound of Evolution
Zonisamide
Mechanism of action:
Zonisamide is a sulfonamide derivative. It inhibits voltage-gated sodium channels, thereby suppressing rapid repetitive neuronal firing and reducing the abnormal continuous generation of action potentials. It also inhibits T-type calcium channels, which decreases neuronal synchronization and stabilizes neural network activity.
Reference(s):
1. Leppik IE et al. (2004). Zonisamide: chemistry, mechanism of action, and pharmacokinetics. Seizure.
2. Ueda Y et al. (2003). Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Res Mol Brain Res.
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