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Actinomycin D/Dactinomycin

放線菌素D

Mechanism of action:

Actinomycin D 主要作用機制是與 DNA 雙股結構中的鳥糞嘌呤-胞嘧啶（G-C）鹼基對插入結合，從而抑制 RNA 聚合酶的活性，阻斷 RNA 的合成，間接干擾蛋白質生成。

​Reference(s):

Wang X et al. (2003). Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol.

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