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The Sound of Evolution
Adapalene
阿達帕林
Mechanism of action:
Adapalene 能選擇性結合皮膚細胞內的視黃酸受體（retinoic acid receptor，RAR-β 與 RAR-γ），調節基因表達，進而促進角質細胞正常分化、抑制角化過度與粉刺形成。此外，它能抑制發炎反應，可減少痤瘡病灶中的發炎與丘疹生成。由於其化學結構穩定，對光與氧較具耐受性，常作為外用視黃酸類藥物使用。
Reference(s):
1. Wang Q et al. (2019). Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem.
2. Wu Q et al. (2022). The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay. Bioorg Med Chem Lett.
3. Liu T et al. (2025). BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data. Nucleic Acids Res.
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