The Sound of Evolution
Aripiprazole
阿立哌唑
Mechanism of action:
Aripiprazole 具有獨特的多重神經傳導調節作用。部分促效於多巴胺 D₂ 受體，在多巴胺量過低時，能適度刺激 D₂ 受體，調節與情緒與動機相關的多巴胺訊號傳遞；在多巴胺量過高時，會競爭性抑制 D₂ 受體活性，降低多巴胺的過度活化訊號，因此可平衡多巴胺系統，而非單純阻斷。此外，也能部分促效於 5-HT₁A 受體，增強血清素活性；並拮抗 5-HT₂A 受體，調節特定皮質-邊緣系統迴路的血清素-多巴胺交互作用。
Reference(s):
1. Nasrallah HA et al. (2008). Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry.
2. Bauman JN et al. (2008). Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug. Drug Metab Dispos.
3. Kubo M et al. (2007). Pharmacokinetics of aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: influence of CYP2D6 polymorphism. Drug Metab Pharmacokinet.