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Atazanavir

阿扎那韋

Mechanism of action:

Atazanavir 會與 HIV-1 蛋白酶（HIV-1 protease）的活性位點結合，此蛋白酶在病毒複製過程中負責將病毒多蛋白前體（gag 與 gag-pol polyproteins）切割成具功能性的酵素蛋白。Atazanavir 阻止了這些酵素蛋白的產生，使新生成的病毒顆粒維持在未成熟且無感染力的狀態。

​Reference(s):

1. Croom KF et al. (2009). Atazanavir: a review of its use in the management of HIV-1 infection. Drugs. 


2. von Hentig N et al. (2008). Atazanavir/ritonavir: a review of its use in HIV therapy. Drugs Today (Barc). 


3. Swainston Harrison T et al. (2005). Atazanavir: a review of its use in the management of HIV infection. Drugs.

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