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The Sound of Evolution
Brimonidine
溴莫尼定
Mechanism of action:
Brimonidine 是一種選擇性 α₂-腎上腺素受體促效劑（selective α₂-adrenergic receptor agonist）。Brimonidine 作用於睫狀體（ciliary body）與視網膜血管的 α₂ 受體，抑制腺苷酸環化酶（adenylyl cyclase），降低 cAMP，進而減少房水分泌；此外也可能影響房水經鞏膜路徑的排出。在皮膚血管上，brimonidine 也是透過皮膚血管的 α₂ 受體，讓微血管收縮，降低皮膚血流相關反應。
Reference(s):
1. Adkins JC et al. (1998). Brimonidine: A review of its pharmacological properties and clinical potential in the management of open-angle glaucoma and ocular hypertension. Drugs Aging.
2. Cantor LB et al. (1997). Brimonidine. Expert Opin Investig Drugs.
3. Cantor LB et al. (2000). The evolving pharmacotherapeutic profile of brimonidine, an alpha 2-adrenergic agonist, after four years of continuous use. Expert Opin Pharmacother.
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