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Bromocriptine

溴隱亭

Mechanism of action:

Bromocriptine 是一種多巴胺受體促效劑（dopamine receptor agonist），屬於麥角（ergot）的衍生物。Bromocriptine 直接刺激腦下垂體的催乳素細胞（prolactin cell）上的 D₂ 受體，抑制腺苷酸環化酶（adenylate cyclase），使 cAMP 下降，降低催乳素合成與釋放。Bromocriptine 也會刺激紋狀體（corpus striatum）的 D₂ 受體，同樣抑制腺苷酸環化酶，調節黑質-紋狀體相關的多巴胺訊號傳導。

​Reference(s):

1. Banihashemi B et al. (2002). Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements. Mol Endocrinol. 


2. Kvernmo T et al. (2008). Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 


3. Lam YW et al. (2000). Clinical pharmacology of dopamine agonists. Pharmacotherapy.

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