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The Sound of Evolution
Carbamazepine
卡馬西平
Mechanism of action:
Carbamazepine 是一種二苯並氮䓬（dibenzazepine）的衍生物。Carbamazepine 能與神經元膜上的電壓門控鈉離子通道（voltage-gated Na⁺ channels）結合，穩定其不活化狀態，阻止過度重複開啟與高頻動作電位產生。
Reference(s):
1. Staines AG et al. (2004). N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7. J Pharmacol Exp Ther.
2. Sisodiya SM et al. (2007). Drug resistance in epilepsy: more twists in the tale. Epilepsia.
3. Tolou-Ghamari Z et al. (2013). A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012. J Res Med Sci.
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