top of page
< Back

Carisoprodol

卡立普多

Mechanism of action:

Carisoprodol 是一種中樞性骨骼肌鬆弛劑（centrally acting skeletal muscle relaxant）。Carisoprodol 的確切機制尚未完全清楚，不過可能作用於脊髓與網狀結構（reticular formation），抑制多突觸反射傳導（polysynaptic reflexes），減少肌張力與不自主肌肉收縮。在肝臟中 carisoprodol 會被 CYP2C19 酵素代謝為甲丙氨酯（meprobamate），甲丙氨酯能促效 GABA_A 受體，具有抗焦慮與鎮靜相關特性。

​Reference(s):

1. Toth PP et al. (2004). Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. Clin Ther. 


2. Chou R et al. (2004). Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage. 


3. Littrell RA et al. (1993). Carisoprodol (Soma): a new and cautious perspective on an old agent. South Med J.

bottom of page