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Clevidipine

氯維地平

Mechanism of action:

Clevidipine 是一種第三代二氫吡啶類鈣離子通道阻斷劑（short-acting dihydropyridine calcium channel blocker）。Clevidipine 主要作用於血管平滑肌細胞上的 L-型鈣通道（L-type calcium channel），阻斷鈣離子由細胞外進入細胞內，減少平滑肌收縮，造成血管擴張。

​Reference(s):

1. Zhang JG et al. (2006). Human cytochrome P450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 


2. Nordlander M et al. (2004). Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control. Cardiovasc Drug Rev. 


3. Wang QD et al. (2002). Time-dependent cardioprotection with calcium antagonism and experimental studies with clevidipine in ischemic-reperfused pig hearts: part I. J Cardiovasc Pharmacol.

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