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The Sound of Evolution
Clindamycin
克林黴素
Mechanism of action:
Clindamycin 是一種林克醯胺類抗生素（lincosamide antibiotic）。Clindamycin 能可逆性結合在細菌核糖體 50S 亞基上，特別是與 23S rRNA 的 peptidyl transferase 中心結合。這能阻止肽鏈延長並干擾轉位（translocation），阻斷蛋白質合成，抑制細菌生長。
Reference(s):
1. Daum RS et al. (2007). Clinical practice: Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med.
2. Klempner MS et al. (1981). Clindamycin uptake by human neutrophils. J Infect Dis.
3. Lamont RF et al. (2005). Can antibiotics prevent preterm birth—the pro and con debate. BJOG.
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