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Clotrimazole

克霉唑

Mechanism of action:

Clotrimazole 是一種咪唑類（imidazole）衍生物。Clotrimazole 能抑制真菌的羊毛甾醇-14α-脫甲基酶（lanosterol 14α-demethylase，CYP51A1），該酵素負責將羊毛固醇（lanosterol）轉化為麥角固醇（ergosterol）。當此步驟被阻斷，真菌的細胞膜結構會變得不完整，且羊毛固醇因為無法轉化而不斷堆積，引起毒性，最終讓真菌生長受抑或死亡。

​Reference(s):

1. Ritter W et al. (1985). Pharmacokinetic fundamentals of vaginal treatment with clotrimazole. Am J Obstet Gynecol. 


2. Crowley PD et al. (2014). Clotrimazole as a pharmaceutical: past, present and future. J Appl Microbiol. 


3. S K et al. (2014). Clotrimazole as a cancer drug: a short review. Med Chem (Los Angeles).

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