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Dicyclomine/Dicycloverine

雙環維林

Mechanism of action:

Dicyclomine 是一種毒蕈鹼型乙醯膽鹼受體拮抗劑（muscarinic acetylcholine receptor antagonist）。Dicyclomine 能與腸道平滑肌的 M₃ 受體結合，阻斷乙醯膽鹼（acetylcholine）與該受體作用，抑制腸道平滑肌之鈣離子內流與收縮反應，減少腸胃蠕動、痙攣與腺體分泌。

​Reference(s):

1. Danhof I et al. (1967). Metabolic dynamics of dicyclomine hydrochloride in man as influenced by various dose schedules and formulations. Toxicol Appl Pharmacol. 


2. Walker BJ et al. (1987). Quantitative analysis of dicyclomine in human plasma by capillary gas chromatography and nitrogen-selective detection. J Chromatogr.

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