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The Sound of Evolution
Dutasteride
度他雄胺
Mechanism of action:
Dutasteride 是一種雄激素抑制劑（antiandrogenic agent），能抑制 5α-還原酶（5-alpha reductase）。人體中存在兩種主要的 5α-還原酶同功酶，type I 分布於皮膚、肝臟、頭皮皮脂腺；type II 分布於攝護腺、精囊、毛囊與生殖器。Dutasteride 可同時抑制 type I 與 type II 酵素，抑制二氫睪酮（dihydrotestosterone）的合成，降低 DHT 介導的攝護腺組織刺激與增生訊號，並可影響下泌尿道阻塞相關生理表現。
Reference(s):
1. Keam SJ et al. (2008). Dutasteride: a review of its use in the management of prostate disorders. Drugs.
2. Shah SK et al. (2009). Phase II study of dutasteride for recurrent prostate cancer during androgen deprivation therapy. J Urol.
3. Arif T et al. (2017). Dutasteride in androgenetic alopecia: an update. Curr Clin Pharmacol.
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