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Finasteride

非那雄胺

Mechanism of action:

Finasteride 是一種 5α-還原酶抑制劑（5α-reductase inhibitor）。5α-還原酶負責將睪酮（testosterone）轉換為二氫睪酮（dihydrotestosterone）。Finasteride 與該酵素結合後，顯著降低二氫睪酮的生成，從而降低二氫睪酮介導的前列腺組織生長訊號。

​Reference(s):

1. Smith AB et al. (2009). Finasteride in the treatment of patients with benign prostatic hyperplasia: a review. Ther Clin Risk Manag. 


2. Agamia NF et al. (2016). Benign prostatic hyperplasia, metabolic syndrome and androgenic alopecia: Is there a possible relationship? Arab J Urol. 


3. Vaughan ED et al. (2003). Long-term experience with 5-alpha-reductase inhibitors. Rev Urol.

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