The Sound of Evolution
Fludrocortisone
氟氫可體松
Mechanism of action:
Fludrocortisone 是一種合成鹽皮質類固醇（synthetic mineralocorticoid），屬於氟化皮質類固醇（fluorinated corticosteroid）衍生物。Fludrocortisone 在腎臟遠曲小管與集尿管的上皮細胞能活化位於細胞質中的鹽皮質激素受體（mineralocorticoid receptor），隨後進入細胞核調控特定基因的轉錄，提升上皮鈉離子通道（ENaC）與鈉甲幫浦（Na⁺/K⁺-ATPase）的表達量，促進鈉離子自尿液回收至血液中，讓血容量與血壓上升，並可用於血容量不足或低血壓相關狀態。
Reference(s):
1. Agarwal MK et al. (1977). Physiological activity and receptor binding of 9 alpha fluorohydrocortisone. Biochem Biophys Res Commun.
2. Lan NC et al. (1982). Binding of steroids to mineralocorticoid receptors: implications for in vivo occupancy by glucocorticoids. J Clin Endocrinol Metab.
3. Diederich S et al. (2002). 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids. J Clin Endocrinol Metab.