top of page
< Back

Furosemide

呋塞米

Mechanism of action:

Furosemide 是一種袢利尿劑（loop diuretic），屬於磺胺類（sulfonamide）衍生物。Furosemide 的利尿作用發生在腎臟亨利氏環的上升段粗枝（thick ascending limb of the loop of Henle），抑制鈉鉀氯共轉運蛋白2（Na⁺/K⁺/2Cl⁻ transporter 2，NKCC2）。正常情況下，NKCC2 負責將鈉、鉀與氯離子從腎小管腔再吸收回細胞。Furosemide 抑制此轉運蛋白活性後，使 NaCl 再吸收大幅下降，導致大量水分隨鈉排出。

​Reference(s):

1. Prandota J et al. (2001). Clinical pharmacology of furosemide in children: a supplement. Am J Ther. 


2. Ponto LL et al. (1990). Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I). Clin Pharmacokinet. 


3. Prandota J et al. (2002). Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseases. Am J Ther.

bottom of page