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Glimepiride

格列美脲

Mechanism of action:

Glimepiride 是一種第三代磺醯尿素類（sulfonylurea）衍生物。Glimepiride 能結合並抑制胰島 β 細胞膜上的磺醯脲受體 1（SUR1），此受體為 ATP-敏感鉀離子通道蛋白（ATP-sensitive potassium channel）的調節亞基。被 glimepiride 抑制後，鉀離子外流減少，細胞膜發生去極化（depolarization）。去極化會造成鈣離子通道（calcium channel）開啟，鈣離子內流增加，促使胰島素釋放。

​Reference(s):

1. Basit A et al. (2012). Glimepiride: evidence-based facts, trends, and observations (GIFTS). Vasc Health Risk Manag. 


2. Massi-Benedetti M et al. (2003). Glimepiride in type 2 diabetes mellitus: a review of the worldwide therapeutic experience. Clin Ther. 


3. Sola D et al. (2015). Sulfonylureas and their use in clinical practice. Arch Med Sci.

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