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The Sound of Evolution
Gonadorelin
戈那瑞林
Mechanism of action:
Gonadorelin 是一種促性腺激素釋放激素（gonadotropin-releasing hormone），屬於下視丘胜肽激素（hypothalamic peptide hormone）。Gonadorelin 與腦下垂體前葉的促性腺激素釋放激素受體（GnRH receptor）結合，活化 Gq/PLC 訊號途徑，促使黃體成長激素（LH）與濾泡刺激素（FSH）分泌增加。黃體成長激素與濾泡刺激素的上升會進一步驅動性腺（睪丸或卵巢）的類固醇生成與配子生成相關生理反應。
Reference(s):
1. Dungan HM et al. (2006). Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology.
2. Franceschini I et al. (2006). Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett.
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