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Guanethidine

胍乙啶

Mechanism of action:

Guanethidine 是一種腎上腺素神經元阻斷劑（adrenergic neuron blocker）。Guanethidine 在交感神經元內會累積於神經末梢與儲存囊泡附近，逐步取代囊泡中的正腎上腺素（norepinephrine），使可釋放的正腎上腺素儲量下降。當神經受到刺激時，由於正腎上腺素儲存不足且釋放受阻，交感神經對心臟與血管的刺激明顯減弱，使血壓降低。

​Reference(s):

1. Joyce PI et al. (2001). Interaction of local anaesthetic agents with the endogenous norepinephrine transporter in SH-SY5Y human neuroblastoma cells. Neurosci Lett. 


2. Yi E et al. (2005). Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia. Auton Neurosci. 


3. Galli A et al. (1996). Norepinephrine transporters have channel modes of conduction. Proc Natl Acad Sci USA.

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