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Hydroxyurea

羥基脲

Mechanism of action:

Hydroxyurea 是一種核苷酸合成抑制劑（ribonucleotide reductase inhibitor）。Hydroxyurea 能抑制核糖核苷酸還原酶（ribonucleotide reductase）的活性，使去氧核糖核苷酸（deoxyribonucleotides）無法生成，導致 DNA 無法複製，進而抑制腫瘤細胞的增殖。Hydroxyurea 也能促進胎兒血紅素（HbF）表達增加，HbF 不易形成鐮刀狀結構，可減少紅血球變形、溶血與血管阻塞。

​Reference(s):

1. Ferrari A et al. (2019). Clinical outcomes under hydroxyurea treatment in polycythemia vera: a systematic review and meta-analysis. Haematologica. 


2. Cortelazzo S et al. (1995). Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. N Engl J Med. 


3. Kim MS et al. (2012). Long-term follow-up result of hydroxyurea chemotherapy for recurrent meningiomas. J Korean Neurosurg Soc.

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