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Lamotrigine

拉莫三嗪

Mechanism of action:

Lamotrigine 的詳細機制尚未清楚，但已知會抑制鈉離子通道（sodium channel）在高頻放電時的活化，減少病理性重複放電。Lamotrigine 透過降低神經末梢的動作電位傳遞，可降低麩胺酸（glutamate）、天門冬胺酸（aspartate）等興奮性神經傳導物質的釋放，從而降低神經網路過度興奮。

​Reference(s):

1. Backonja M et al. (2004). Neuromodulating drugs for the symptomatic treatment of neuropathic pain. Curr Pain Headache Rep. 


2. Barbosa L et al. (2003). A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J Clin Psychiatry. 


3. Jensen TS et al. (2002). Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain.

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