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The Sound of Evolution
Levetiracetam
左乙拉西坦
Mechanism of action:
Levetiracetam 是一種吡咯烷酮（pyrrolidone）衍生物。Levetiracetam 高親和力結合位於突觸前神經末梢的突觸囊泡蛋白 2A（synaptic vesicle protein 2A），這是一種調控神經傳導物質釋放的重要囊泡膜蛋白。經由調節囊泡融合與釋放過程，levetiracetam 可降低過度同步化的神經放電，特別是在病理性興奮狀態下，對正常神經傳導影響相對較小。透過穩定神經網路活動，減少神經元過度興奮與異常放電，降低癲癇樣放電的發生。
Reference(s):
1. Patsalos PN et al. (2004). Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet.
2. Baltes S et al. (2007). Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology.
3. Luna-Tortos C et al. (2008). Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology.
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