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The Sound of Evolution
Mecamylamine
美卡拉明
Mechanism of action:
Mecamylamine 是一種神經節阻斷劑（ganglionic blocker），屬於菸鹼型乙醯膽鹼受體拮抗劑（nicotinic acetylcholine receptor antagonist）。Mecamylamine 會阻斷位於自律神經節（交感與副交感） 上的菸鹼型乙醯膽鹼受體（nicotinic acetylcholine receptor），主要為 α3β4，抑制乙醯膽鹼（acetylcholine）在節前與節後神經元之間的訊號傳遞。
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Struthers AM et al. (2009). Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacol Biochem Behav.
3. Shytle RD et al. (2002). Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens.
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