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The Sound of Evolution
Mefenamic acid
甲芬那酸
Mechanism of action:
Mefenamic acid 是一種鄰胺基苯甲酸類（anthranilic acid）衍生物。Mefenamic acid 能抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻止將花生四烯酸（arachidonic acid）轉換為前列腺素（prostaglandin），降低前列腺素介導的發炎訊號、疼痛敏感化與發燒反應。
Reference(s):
1. Gierse JK et al. (1995). Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J.
2. Bhat AS et al. (2007). Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study. Eur J Pharmacol.
3. Bhat AS et al. (2005). Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study. Eur J Pharmacol.
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