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The Sound of Evolution
Mesalazine/Mesalamine
美沙拉嗪
Mechanism of action:
Mesalazine，又稱 5-氨基水楊酸（5-aminosalicylic acid）。Mesalazine 能抑制環氧化酶（COX）與脂氧化酶（LOX）路徑，減少前列腺素（prostaglandins）和白三烯（leukotrienes）的生成。Mesalazine 也會抑制 NF-κB 的活化，減少發炎細胞激素（如 TNF-α、IL-1、IL-6）的表達。由此降低腸道局部發炎反應。
Reference(s):
1. Mayberry J et al. (2013). The history of 5-ASA compounds and their use in ulcerative colitis--trailblazing discoveries in gastroenterology. J Gastrointestin Liver Dis.
2. Stolfi C et al. (2013). Mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDs) and mesalazine in the chemoprevention of colorectal cancer. Int J Mol Sci.
3. Bantel H et al. (2000). Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol.
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