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Methoxamine

甲氧明

Mechanism of action:

Methoxamine 是一種選擇性 α₁-腎上腺素受體促效劑（selective α₁-adrenergic agonist）。Methoxamine 會結合於週邊血管（特別是小動脈與靜脈）平滑肌細胞表面的 α₁ 受體，啟動 Gq 蛋白訊號途徑，使磷脂酶 Cβ（phospholipase Cβ）活化，讓細胞內 IP₃ 與 DAG 增加，細胞質鈣離子濃度上升與活化蛋白激酶 C（protein kinase C），進而導致血管平滑肌收縮。

​Reference(s):

1. Satoh M et al. (1994). Alpha 1-adrenoceptor subtypes mediating the regulation and modulation of Ca2+ sensitization in rabbit thoracic aorta. Eur J Pharmacol. 


2. Suzuki E et al. (1990). Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role. Mol Pharmacol.

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